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Computer simulations visualize how DNA is recognized to convert cells into stem cells

Computer simulations visualize how DNA is recognized to convert cells into stem cells

The pioneer transcription factor Oct4 (blue) binds to the nucleosome (a complex of proteins (green) and the DNA (orange) wrapped around these proteins). Credit: Jan Huertas and Vlad Cojocaru, ©MPI Münster, ©Hubrecht Institute Researchers of the Hubrecht Institute (KNAW – The Netherlands) and the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of [Read More...]
Closer to Identifying Leukemic Stem Cells

Closer to Identifying Leukemic Stem Cells

Researchers at the Josep Carreras Leukaemia Research Institute have developed an innovative diagnostic assay to identify cells resistant to leukemia treatment. Representative flow cytometric study of the alkaline phosphatase activity in a patient of the ALP ? 12% group. Alkaline phosphatase positive cells are represented in combination with CD34 staining at diagnosis (upper row) and after relapse (lower row). Reference contour plots for two bone [Read More...]
Multiple doses of stem cells show potential in treating severe asthma

Multiple doses of stem cells show potential in treating severe asthma

A study released today in STEM CELLS Translational Medicine (SCTM) describes how multiple doses of a type of stem cell called mesenchymal stromal cells (MSCs) might offer a new way to treat people suffering from severe asthma. An asthma attack is triggered by allergens entering the lungs and causing swelling of the airways. This sets off a domino effect that results in narrowing of the airways from the nose and mouth to the lungs. The most [Read More...]

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